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EX-527 was administered by intracerebroventricular injection to rats at 5-10 µg to increase hypothalamic acetyl-p53 levels by inhibiting hypothalamic SIRT1 activity (formulation: dissolved in DMSO in a total volume of 5 μL)
Smiles: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O[C@H](COC(=O)/C=C/C3=CC(O)=C(O)C=C3)[C@H]2O)OCCC2C=C(O)C(O)=CC=2)[C@H](O)[C@H](O)[C@H]1O
also known as RTA-401 and CDDO
4-benzodioxin-6-yl)-2-methylphenyl]methoxy}phenyl}methyl)-4-hydroxypyrrolidine-2-carboxylic acid
Leukotriene D4 251D-646 EX-527 was administered by intracerebroventricularLeukotriene D4 is one of the constituents of slow reacting substance of anaphylaxis (SRS A) produced by the metabolism of LTC4 by glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl leukotriene metabolite of LTC4. Leukotriene D4 induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. Product information CAS Number: 73836 78 9 Molecular Weight: 496. 66 Formula:
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