PX-478 - Hypoxia-inducible Factor-1α (HIF-1α) Inhibitor. CAS# 685898-44-6 0418 is a highly potent and

is a highly potent and selective small molecule inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK)

BRD3 and BRD4 with IC50 of 10-19 nM

including DNA replication

pancreatic

PX-478 - Hypoxia-inducible Factor-1α (HIF-1α) Inhibitor. CAS# 685898-44-6 0418 is a highly potent andPX 478, CAS No. 685898 44 6, is HIF 1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1 alpha inhibitor PX 478 appears to inhibit hypoxia inducible factor 1 alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation,