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Smiles: CN(C)CCNC(=O)C1=CC=CN2C1=NC1C=C3C=CC=CC3=CC1C2=O
is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis
ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30
InChiKey: SPFYMRJSYKOXGV-UHFFFAOYSA-N
FM-381 oxetine hydrochloride hemihydrate Smiles: CN(C)CCNC(=O)C1=CC=CN2C1=NC1C=C3C=CC=CC3=CC1C2=OFM 381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM 381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600 fold selectivity over JAK1, JAK2 and TYK2, respectively. Product information CAS Number: 2226521 65 7 Molecular Weight: 428. 49 Formula: C24H24N6O2 Chemical Name: (2E) 2 cyano 3 (5 {3 cyclohexyl 3, 5, 8, 10 tetraazatricyclo[7. 3. 0. 0, ]dodeca 1, 4, 6, 8, 11 pentaen 4 yl}furan 2 yl) N, N dimethylprop 2
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