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pii: S0889-1591(15)00428-6
A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates
and the Ki values for EGFRL858R/T790M and EGFRWT are 21
CAS Number: 36085-73-1
A-867744 - CAS# 1000279-69-5 terin) pii: S0889-1591(15)00428-6A 867744 is a type II PAM with good potency and selectivity. A 867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A 867744 normalized gating deficits. A 867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A 867744 potentiated acetylcholine (ACh) evoked currents, with an EC(50) value of approximately 1
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