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both Ciclesonide (CIC) and Desisobutyryl-ciclesonide (des-CIC) induce a dose-dependent downregulation of PhlP5-induced proliferation
InChi: InChI=1S/C18H23N3O3/c19-10-3-1-2-5-12-6-4-7-13-14(12)11-21(18(13)24)15-8-9-16(22)20-17(15)23/h4
which inhibits TOPK kinase activity with a median inhibitory concentration (IC50) value of 2
Smiles: CN(C)C(=S)CC1C(=O)N(CC2C=CC(=CC=2)C2=CC=CC=C2C2NN=NN=2)C(CCCC)=NC=1C
Fmoc-NH-PEG2-CH2CH2COOH Catalog No.:M26766-C both Ciclesonide (CIC) and Desisobutyryl-ciclesonideFmoc NH PEG2 CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs). Fmoc NH PEG2 CH2CH2COOH is also a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 872679 70 4 Molecular Weight: 399. 44 Formula: C22H25NO6 Chemical Name: 3 {2 [2 ({[(9H fluoren 9 yl)methoxy]carbonyl}amino)ethoxy]ethoxy}propanoic acid Smiles: OC(=O)CCOCCOCCNC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21