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Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells
2013 Aug 9
Solubility: DMSO : 100 mg/mL (214
amazonensis promastigotes and amastigotes (IC50s=13
K 01-162 nocitrin Recognition of Vitamin B PrecursorsK 01 162 (K162) binds and destabilizes AO ( amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50) Target: Amyloid in vitro: The active drug candidate K162 (EC50 = 0. 080 M), stabilizes hydrophobic core I of A42 peptide (residues 17 21) to its helical conformation by interacting specifically in this region. K01 162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 M. in vivoK01 162 can reduce the brain amyloid
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