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AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research
InChi: InChI=1S/C19H26N2S
Chemical Name: 3-(3-(1-cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide
Smiles: COC1C=CC(CN2C(=NN=C2CCC2C=CC=CC=2)[C@@H](CC2=CNC3C=CC=CC2=3)NC(=O)CN)=CC=1
ML-095 (hydrochloride) 22717 AES-350 triggers apoptosis in AMLML 095 (hydrochloride) is a specific PLAP inhibitor . Alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. There are three isozymes of alkaline phosphatases: placental alkaline phosphatase (PLAP), intestinal alkaline phosphatase (IAP), and tissue non specific alkaline phosphatase (TNAP). Placental alkaline phosphatase (PLAP) is highly
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