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MLN8237 induced polyploidization and expression of mature megakaryocyte markers in acute megakaryocytic leukemia (AMKL) blasts and displayed potent anti-AMKL activity in vivo
Treshkur T
Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development
4]oxazepin-4(5H)-yl)propan-1-one
AI-10-49 - CAS# 1256094-72-0 60268 MLN8237 induced polyploidization and expressionAI 10 49, CAS No. 1256094 72 0, is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the
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