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InChiKey: UCINOBZMLCREGM-RNNUGBGQSA-N
) protects bone and cartilage from degradation
AZD2014 was orally dosed to mice at 2
PNU 282987 has negligible activity against α1β1γδ and α3β4 nAChRs as well as a panel of monoamine
AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid InChiKey: UCINOBZMLCREGM-RNNUGBGQSA-NAK 7, CAS No. 420831 40 9, is a cell and brain permeable, selective sirtuin SIRT2 inhibitor (IC50 ~15. 5 M). AK 7 displays no effect on SIRT1 or SIRT3. It diminishes neuronal cell death induced by mutant huntingtin fragment. It also down regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. In two genetic mouse models of Huntingtons disease, AK 7 treatment resulted in improved motor function,
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