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Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels
Smiles: NC(=O)C1=CN=C(NCCC2=CC(Cl)=C(O)C=C2)N=C1NCC1C=CC=CC=1
enhances cholesterol 7α-hydroxylase (CYP7A1) activity
HDAC3 inhibition promotes a distinct pattern of histone acetylation linked to gene expression within the infralimbic cortex
Bictegravir 51322 Further assessment in both acuteBictegravir (GS 9883) is a potent inhibitor of HIV 1 integrase with an IC50 of 7. 5 nM. Product information CAS Number: 1611493 60 7 Molecular Weight: 449. 38 Formula: C21H18F3N3O5 Chemical Name: (1S,11R,13R) 5 hydroxy 3,6 dioxo N [(2,4,6 trifluorophenyl)methyl] 12 oxa 2,9 diazatetracyclo[11. 2. 1. 0,. 0,]hexadeca 4,7 diene 7 carboxamide Smiles: OC1=C2C(=O)N3[C@@H](CN2C=C(C(=O)NCC2C(F)=CC(F)=CC=2F)C1=O)O[C@H]1C[C@@H]3CC1 InChiKey: SOLUWJRYJLAZCX
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