Monoacylglycerol Lipase Inhibitor 21 lorate Smiles: CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)N1C3C(=C4C(O)NC(=O)C4=C4C=3N2C2=CC=CC=C24)C2=CC=CC=C12)NC

Smiles: CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)N1C3C(=C4C(O)NC(=O)C4=C4C=3N2C2=CC=CC=C24)C2=CC=CC=C12)NC

Formula: C12H17N3O3S

Concentration-response curves for Cinaciguat are constructed after 1 min exposure in the presence of sildenafil

Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2

Monoacylglycerol Lipase Inhibitor 21 lorate Smiles: CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)N1C3C(=C4C(O)NC(=O)C4=C4C=3N2C2=CC=CC=C24)C2=CC=CC=C12)NCKi: 0. 4 M for MAGL Monoacylglycerol Lipase Inhibitor 21 is an inhibitor of monoacylglycerol lipase (MAGL) and FAAH. Endocannabinoids such as 2 arachidonoyl glycerol (2 AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids involved in various synaptic processes including activation of cannabinoid receptors. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of AEA and 2 AG, respectively. In