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HFD mice have a marked increase in the number of F4/80 crown-like structures (+95%
P110δ-IN-1
Solubility: DMSO: 71 mg/mL(198
44)45)32(41)37(22)20-26-11-6-10-25-12-7-17-34-30(25)26/h3-17
Roscovitine (Seliciclib) D318088 HFD mice have a markedSeliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small molecule cyclin dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2 E, CDK2 A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK mediated phosphorylation of the carboxy terminal domain
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