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RN-1 was administered by intraperitoneal injection once a day at a dose of 10-30 mg/kg to the novel object recognition (NOR) mouse model
Formula: C18H20ClFN2O2
) (Note: PYR-41 in solution may exist as a mixture of E- and Z- isomers
5% methylcellulose
FPS-ZM1 - CAS# 945714-67-0 0078 RN-1 was administered by intraperitonealFPS ZM1, CAS No. 945714 67 0, is a high affinity RAGE specific blocker that inhibits amyloid binding to RAGE, neurological damage and inflammation in the APP(sw 0) transgenic mouse model of AD. FPS ZM1 is not toxic to mice and can easily cross the blood brain barrier. AGEs administration induced an regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are
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