MERcK-5 - CAS# 457081-03-7 Catalog No.:M6539-2 Smiles: CC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1CCC(O)=O

Smiles: CC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1CCC(O)=O

Formulation is 1% (v/v) solution of ethanol/solutol/water (10/40/50%)

InChi: InChI=1S/C40H50N8O6

is a selective inhibitor of HDAC3

MERcK-5 - CAS# 457081-03-7 Catalog No.:M6539-2 Smiles: CC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1CCC(O)=OPyridone 6, also known CMP 6 or JAK Inhibitor I, CAS No. 457081 03 7, is a pan Janus activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down regulation of receptor activator of nuclear factor kappaB (NF kappaB) ligand (RANKL) induced c