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Van Dongen M
activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis
non-essential amino acid in the human body and one of the few amino acids that can directly cross the bloodâbrain barrier
induces glioma cell apoptosis through JNK activation and inhibits telomerase activity
YKL-5-124 TFA Catalog No.:M14492-2 Van Dongen MYKL 5 124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53. 5 nM and 9. 7 nM for CDK7 and CDK7 Mat1 CycH, respectively. YKL 5 124 TFA is >100 fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL 5 124 TFA induces a strong cell cycle arrest, inhibits E2F driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status. Product information
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