would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration
In vivo pharmacokinetics (PK) in rats shows low CL and high oral bioavailability
InChiKey: WDHYUBIJZHYUOV-UHFFFAOYSA-N
Succinic-2,2,3,3-d4 acid Catalog No.:M33411-10 would result in 60-70% occupancySuccinic acid [2, 2, 3, 3 d4] is a labelled form of Succinic acid, which is isolated from the rhizome of Gastrodia elata. Product information CAS Number: 14493 42 6 Molecular Weight: 122. 11 Formula: C4H6O4 Chemical Name: (H)butanedioic acid Smiles: [2H]C([2H])(C(O)=O)C([2H])([2H])C(O)=O InChiKey: KDYFGRWQOYBRFD LNLMKGTHSA N InChi: InChI=1S C4H6O4 c5 3(6)1 2 4(7)8 h1 2H2,(H,5,6)(H,7,8) i1D2,2D2 Technical Data Appearance: Solid Power Purity: 98% (or