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Burns-Kurtis CL
57(10):4333-40
CAS Number: 2503-26-6
Formula: C22H28N2O3
FK 866 hydrochloride emodin Burns-Kurtis CLFK 866 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 values ranging between 0. 09nM and 27. 2nM . NAD plays a vital role in numerous biochemical and biologic processes. Targeting NAD synthesis is thought to be a selective manner to kill cancer cells since cancer cells have a higher rate of NAD turnover compared with normal cells. In the vitro MTT assay using a panel of 41 human hematologic cancer cell
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