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10 mg/kg/day
InChiKey: QDUIJCOKQCCXQY-WHJQOFBOSA-N
A-867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs
2012 Apr 15
Actinonin 649 10 mg/kg/dayActinonin (( ) Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0. 28 nM. Actinonin also inhibits MMP 1, MMP 3, MMP 8, MMP 9, and hmeprin with Ki values of 300 nM, 1, 700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer.
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