Deguelin Acetyltransferase Inhibitor II Smiles: CC1=C(C=C2SC(=O)N(C3C=CC=CC=3)C2=O)C=C(C)N1C1=CN=CC=C1

Smiles: CC1=C(C=C2SC(=O)N(C3C=CC=CC=3)C2=O)C=C(C)N1C1=CN=CC=C1

30(18):2183-9

Smiles: CN1C=C(C2=C(C3=CN(CCCSC(N)=N)C4=CC=CC=C34)C(=O)NC2=O)C2=CC=CC=C12

PubMed Central PMCID: PMC3981813

Deguelin Acetyltransferase Inhibitor II Smiles: CC1=C(C=C2SC(=O)N(C3C=CC=CC=3)C2=O)C=C(C)N1C1=CN=CC=C1Deguelin is a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti tumor effect on several cancers. Deguelin displays anti cancer activity by inhibiting the growth of pre cancerous and cancerous cells particularly for lung cancer. So far the compound has shown no toxic effects on normal cells. However, high doses of deguelin are suspected of having negative effects on the heart, lungs and nerves. The molecular mechanisms