SKI-II - CAS# 312636-16-1 size:10mg solid 86±33 μM

86±33 μM

Cameron DJ

It is also an endogenous active metabolite and analogue of the neurotransmitter γ-aminobutyric acid (GABA)

and has been useful in characterising the orexinergic regulation of brain systems involved with appetite and sleep

SKI-II - CAS# 312636-16-1 size:10mg solid 86±33 μMSKI II, CAS No. 312636 16 1, is a selective non lipid inhibitor of sphingosine kinase (IC50 = 0. 5 M). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI II was more efficient than two known SphK1 inhibitors SK1 I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI II was almost reversed by the general caspase inhibitor z VAD fmk. SKI II treatment inhibited