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2007 Oct 28
24 hours) activates p53 to enhance radiosensitivity in AGS and MKN45 cells
WO 2018136700 A1 20180726
despite target engagement
Losartan Carboxaldehyde 6681509 2007 Oct 28Losartan is an inhibitor of endothelial cyclooxygenase (COX) 2. COX 2 produces prostaglandins that inhibit apoptosis and stimulate angiogenesis and invasiveness, and thus selective COX 2 inhibitors can reduce prostaglandin synthesis and restore apoptosis. In vitro: Losartan is an intermediate aldehyde metabolite of losartan, the angiotensin II type 1 receptor antagonist. Losartan could not block angiotensin receptors, but inhibit the expression of