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EHT 5372 (0
and an antiglaucoma agent
At this time point
with treatment resulting in marked increases in periosteal bone formation and cortical thickness in ovariectomized monkeys whereas trabecular bone formation is reduced
BACE-1 inhibitor 2 6780 EHT 5372 (0BACE 1 inhibitor 2 is a potent and CNS permeable BACE 1 inhibitor with an IC50 of 1. 5 nM in BACE 1 enzymatic assay. Product information Molecular Weight: 467. 42 Formula: C21H21F4N5O3 Chemical Name: N [3 [(4aS, 6S, 8aS) 2 amino 3, 3 difluoro 6 methyl 4a, 5, 6, 8 tetrahydro 4H pyrano[3, 4 b]pyridin 8a yl] 4 fluorophenyl] 5 (fluoromethoxy)pyrazine 2 carboxamide Smiles: C[C@H]1C[C@H]2CC(F)(F)C(N)=N[C@]2(CO1)C1=CC(=CC=C1F)NC(=O)C1=CN=C(C=N1)OCF InChiKey:
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