ABBV-744 - CAS# 2138861-99-9 48671 Entecavir-triphosphate is a highly potent

Entecavir-triphosphate is a highly potent inhibitor of wild-type HBV Pol and is 100- to 300-fold more potent than lamivudine-triphosphate against 3TC-resistant HBV Pol

was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design

PNU 100592

Roberta Costi

ABBV-744 - CAS# 2138861-99-9 48671 Entecavir-triphosphate is a highly potentABBV 744 is a first in class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values range from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV 744 is primarily metabolized by CYP3A4 with drug like properties enable the investigation of its antitumor efficacy and tolerability. Product information CAS Number: 2138861 99 9 Molecular Weight: 491. 55 Formula: C28H30FN3O4 Chemical Name: N ethyl 4 [2 (4 fluoro 2,6