NRX-252114 ncristine Discovery of Small Molecules Targeting

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

a furfuran lignan

EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2)

Anticancer Agents Med Chem

NRX-252114 ncristine Discovery of Small Molecules TargetingNRX 252114 is a potent enhancer of the interaction between catenin, and its cognate E3 ligase, SCF TrCP. NRX 252114 enhances the binding of pSer33 S37A catenin peptide for TrCP with an EC50 of 6. 5 nM and a Kd of 0. 4 nM. NRX 252114 induces mutant catenin degradation. Product information Molecular Weight: 510. 32 Formula: C22H12Cl2F3N3O2S Chemical Name: 2 {4 [(2,6 dichlorophenyl)sulfanyl] 2 oxo 6 (trifluoromethyl) 1,2 dihydropyridine 3 carbonyl} 2,3