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Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid]
InChiKey: ULUBAPWNHROTEU-UHFFFAOYSA-N
(2010) Autophagy
Smiles: C[C@]12O[C@H](C[C@]1(O)C(O)=O)N1C3=C4C(=C5CNC(=O)C5=C3C3=CC=CC=C13)C1=CC=CC=C1N24
Eltrombopag MZ 1 Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid]Eltrombopag is a small molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was
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