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displaying 13 to 15-fold more potent inhibition of survival of the WT cells than the CRBN-/- cells
WO 2018136700 A1 20180726
CAS Number: 47142-51-8
2'-((9-isopropyl-6-((4-methoxybenzyl)amino)-9H-purin-2-yl)azanediyl)bis(ethan-1-ol)
Pomalidomide HCl displaying 13 to 15-fold morePomalidomide, also known as CC4047, is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody dependent cellular cytotoxicity (ADCC). Pomalidomide was approved on February 8,
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