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You can either run that creature into blockers, or sacrifice it to one of your own abilities for a benefit

2011-06-01 If one or more creatures an opponent controls are put into the graveyard at the same time as Sangromancer, Sangromancer's first ability will trigger that many times.

The second situation comes up when you dredge to replace multiple draws at once, such as with Cathartic Reunion

13 Toughness Matters The Best Offense Is A Good Defense Ever since the release of Doran, the Siege Tower back in Lorwyn, Commander decks built around creatures with high toughness and little to no power have been viable in the format