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18 nM and 8 nM
Pearson RB
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs
PubMed PMID: 31137964
SAR-20347 Size:100mg solid 18 nM and 8 nMSAR 20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0. 6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR 20347 inhibits TYK2 and JAK1 mediated IL 12 and IFN signaling. Product information CAS Number: 1450881 55 6 Molecular Weight: 444. 84 Formula: C21H18ClFN4O4 Chemical Name: 2 (2 Chloro 6 fluorophenyl) 5 [[4 (4 morpholinylcarbonyl)phenyl]amino] 4 oxazolecarboxamide Smiles: